Article
High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis.
PloS one - 1 Jan 2015
Pietersen Elize, Peter Jonny, Streicher Elizabeth, Sirgel Frik, Rockwood Neesha, Mastrapa Barbara, Te Riele Julian, Davids Malika, van Helden Paul, Warren Robin, Dheda Keertan
Abstract excerpt
BACKGROUND: There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin has therapeutic benefit despite microbiological resistanc...
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