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Article

Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.

BMC infectious diseases - 26 Oct 2016

Dookie Navisha, Sturm A Willem, Moodley Prashini

Abstract excerpt

BACKGROUND: In South Africa, drug resistant tuberculosis is a major public health crisis in the face of the colossal HIV pandemic. METHODS: In an attempt to understand the distribution of drug resistance in our setting, we analysed the rpoB, katG, inhA, pncA and embB genes associated with resistance to key drugs used in the treatment of tuberculosis in clinical isolates of Mycobacterium tuberculosis in the...

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PMID: 27784282
DOI: 10.1186/s12879-016-1906-3
PMCID: PMC5080726

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