Article
IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae.
Clinical immunology (Orlando, Fla.) - 1 Feb 2016
Grazioli Serge, Hamilton Sara J, McKinnon Margaret L, Del Bel Kate L, Hoang Linda, Cook Victoria E, Hildebrand Kyla J, Junker Anne K, Turvey Stuart E
Abstract excerpt
In this Letter to the Editor we report the case of two siblings with fatal pneumococcal meningitis as the initial manifestation of IRAK-4 deficiency caused by previously undescribed mutations in IRAK4. The letter also highlights the importance of invasive pneumococcal infection as a critical 'red flag' warning of the potential for an underlying primary immunodeficiency and identifies some of the challenges in...
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