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MAGMA: Generalized Gene-Set Analysis of GWAS Data

17 Apr 2015

Abstract excerpt

By aggregating data for complex traits in a biologically meaningful way, gene and gene-set analysis constitute a valuable addition to single-marker analysis. However, although various methods for gene and gene-set analysis currently exist, they generally suffer from a number of issues. Statistical power for most methods is strongly affected by linkage disequilibrium between markers, multi-marker associations are...

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PMID: 25885710
DOI: 10.1371/journal.pcbi.1004219

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