Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation.

doi:10.1007/s10928-025-09969-4

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Article

Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation.

Journal of pharmacokinetics and pharmacodynamics - 4 Apr 2025

Pan Xian, Rowland Yeo Karen

Abstract excerpt

About 15-20% of women experience postnatal depression and may seek advice about medication use whilst breastfeeding. Venlafaxine is a potent and selective neuronal serotonin-norepinephrine reuptake inhibitor indicated for treating major depressive disorders. The drug is mainly metabolised by cytochrome P450 2D6 (CYP2D6) to its active metabolite O-desmethylvenlafaxine (ODV), with small contributions from CYP2C9...

Read the complete abstract on PubMed

Topics

Models, Theoretical
Genotype
Breast Feeding
Venlafaxine Hydrochloride
Desvenlafaxine Succinate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cytochrome P-450 Enzyme System

Lactation

Milk, Human

Humans

Female

Infant, Newborn

Adult

Cytochrome P-450 CYP2D6

Cytochrome P-450 CYP2C19

Source

Open in PubMed Open full text

Identifiers

PMID: 40185984
DOI: 10.1007/s10928-025-09969-4
PMCID: PMC11971150

Genes

CYP2C19
CYP2C9
CYP3A4

Provenance

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