Article
Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration - 27 Mar 2015
Chiasserini Davide, Paciotti Silvia, Eusebi Paolo, Persichetti Emanuele, Tasegian Anna, Kurzawa-Akanbi Marzena, Chinnery Patrick F, Morris Christopher M, Calabresi Paolo, Parnetti Lucilla, Beccari Tommaso
Abstract excerpt
BACKGROUND: Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson's disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a common genetic risk factor for PD. Recently, GCase activity has been shown to be decreased in substantia nigra and in cerebrospinal fluid of...
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