Article
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.
Molecular neurodegeneration - 8 Nov 2019
Huebecker Mylene, Moloney Elizabeth B, van der Spoel Aarnoud C, Priestman David A, Isacson Ole, Hallett Penelope J, Platt Frances M
Abstract excerpt
BACKGROUND: Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson's disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified in PD, implicating lysosomal dysfunction more broadly as a key risk factor for PD. Despite the evidence of multiple lysosomal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.