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Article

Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease.

Journal of neurochemistry - 1 Oct 2012

Kurzawa-Akanbi Marzena, Hanson Peter S, Blain Peter G, Lett Debra J, McKeith Ian G, Chinnery Patrick F, Morris Christopher M

Abstract excerpt

Lewy body disease (LBD) development is enhanced by mutations in the GBA gene coding for glucocerebrosidase (GCase). The mechanism of this association is thought to involve an abnormal lysosomal system and we therefore sought to evaluate if lysosomal changes contribute to the pathogenesis of idiop...

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Source

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Identifiers

PMID: 22803570
DOI: 10.1111/j.1471-4159.2012.07879.x
PMCID: PMC3494984

Genes

LAMP1
LAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22803570-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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