Article
Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease.
BMC neurology - 28 Mar 2015
Yokoyama Jennifer S, Bonham Luke W, Sears Renee L, Klein Eric, Karydas Anna, Kramer Joel H, Miller Bruce L, Coppola Giovanni
Abstract excerpt
BACKGROUND: Heritability of Alzheimer's disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numerous other common variants contributing only modest risk for disease. Variability in clinical presentation of AD, which is typically amnestic (AmnAD) but can less commonly involve visuospatial,...
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