Article
miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression.
The Journal of pathology - 1 May 2008
Wang M, Tan L P, Dijkstra M K, van Lom K, Robertus J-L, Harms G, Blokzijl T, Kooistra K, van T'veer M B, Rosati S, Visser L, Jongen-Lavrencic M, Kluin P M, van den Berg A
Abstract excerpt
Several miRNAs have been reported to be associated with immunoglobulin heavy chain (IgH) mutation and ZAP-70 expression status in blood samples of B-cell chronic lymphocytic leukaemia/small lymphocytic lymphoma (B-CLL/SLL). In the bone marrow and lymphoid tissues, proliferation centres (PCs) represent an important site of activation and proliferation of the neoplastic cells, suggesting that these tissues better...
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