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Article

Follicular histotypes of oncocytic thyroid carcinomas do not carry mutations of the BRAF hot-spot.

World journal of surgery - 1 May 2008

Musholt Petra B, Musholt Thomas J, Morgenstern Saskia C, Worm Karl, Sheu Sien-Yi, Schmid Kurt W

Abstract excerpt

BACKGROUND: The BRAF V600E mutation is the most prevalent genetic aberration in papillary thyroid carcinomas (PTCs), and it is found exclusively in RET/PTC-negative tumors. In oncocytic (Hürthle cell, oxyphilic) thyroid tumors, the presence of RET/PTC rearrangements is associated with either the conventional papillary histotype or the "solid" Hürthle cell tumors, whereas all predominantly follicular oncocytic...

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Share to Adenocarcinoma, Follicular
Share to Adenoma, Oxyphilic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Carcinoma, Papillary

Share to Cohort Studies

Share to DNA Mutational Analysis

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 18235983
DOI: 10.1007/s00268-007-9431-6

Genes

BRAF
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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