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Article

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution.

Science translational medicine - 15 Apr 2015

McGranahan Nicholas, Favero Francesco, de Bruin Elza C, Birkbak Nicolai Juul, Szallasi Zoltan, Swanton Charles

Abstract excerpt

Deciphering whether actionable driver mutations are found in all or a subset of tumor cells will likely be required to improve drug development and precision medicine strategies. We analyzed nine cancer types to determine the subclonal frequencies of driver events, to time mutational processes du...

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Source

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Identifiers

PMID: 25877892
DOI: 10.1126/scitranslmed.aaa1408
PMCID: PMC4636056

Genes

IDH1
ATXN1
BRAF
CTNNA2
EGFR
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25877892-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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