High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour‐initiating properties of colon cancer stem cells

Abstract excerpt

Chronic inflammation is a leading cause of neoplastic transformation in many human cancers and especially in colon cancer (CC), in part due to tumour promotion by nitric oxide (NO) generated at inflammatory sites. It has also been suggested that high NO synthesis, secondary to inducible NO synthase (iNOS) expression, is a distinctive feature of cancer stem cells (CSCs), a small subset of tumour cells with...

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