NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium

Abstract excerpt

Valvular and vascular calcification are common causes of cardiovascular morbidity and mortality. Developing effective treatments requires understanding the molecular underpinnings of these processes. Shear stress is thought to play a role in inhibiting calcification. Furthermore, NOTCH1 regulates vascular and valvular endothelium, and human mutations in NOTCH1 can cause calcific aortic valve disease. Here, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caveolin-1 and cellular processes
• Share to Connective tissue disorders research
• Share to Parathyroid Disorders and Treatments