Article
Phenotypic Heterogeneity in Expression of the K1 Polysaccharide Capsule of Uropathogenic Escherichia coli and Downregulation of the Capsule Genes during Growth in Urine.
Infection and immunity - 1 Jul 2015
King Jane E, Aal Owaif Hasan A, Jia Jia, Roberts Ian S
Abstract excerpt
Uropathogenic Escherichia coli (UPEC) is the major causative agent of uncomplicated urinary tract infections (UTI). The K1 capsule on the surface of UPEC strains is a key virulence factor, and its expression may be important in the onset and progression of UTI. In order to understand capsule expression in more detail, we analyzed its expression in the UPEC strain UTI89 during growth in rich medium (LB medium) and...
Topics
- Antigens, Bacterial
- Artificial Gene Fusion
- Bacterial Adhesion
- Bacterial Capsules
- Cell Line
- Culture Media
- Epithelial Cells
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Genes, Reporter
- Green Fluorescent Proteins
- Humans