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Discovery of New Genes Involved in Curli Production by a Uropathogenic Escherichia coli Strain from the Highly Virulent O45:K1:H7 Lineage.

mBio - 21 Aug 2018

Nhu Nguyen Thi Khanh, Phan Minh-Duy, Peters Kate M, Lo Alvin W, Forde Brian M, Min Chong Teik, Yin Wai-Fong, Chan Kok-Gan, Chromek Milan, Brauner Annelie, Chapman Matthew R, Beatson Scott A, Schembri Mark A

Abstract excerpt

Curli are bacterial surface-associated amyloid fibers that bind to the dye Congo red (CR) and facilitate uropathogenic Escherichia coli (UPEC) biofilm formation and protection against host innate defenses. Here we sequenced the genome of the curli-producing UPEC pyelonephritis strain MS7163 and showed it belongs to the highly virulent O45:K1:H7 neonatal meningitis-associated clone. MS7163 produced curli at human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30131362
DOI: 10.1128/mBio.01462-18
PMCID: PMC6106082

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