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Genetic requirements for uropathogenic E. coli proliferation in the bladder cell infection cycle

17 Sept 2024

Abstract excerpt

ABSTRACT Uropathogenic Escherichia coli (UPEC) requires an adaptable physiology to survive the wide range of environments experienced in the host, including gut and urinary tract surfaces. To identify UPEC genes required during intracellular infection, we developed a transposon-directed insertion-site sequencing approach for cellular infection models and searched for genes in a library of ~20,000 UTI89...

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PMID: 39287381
DOI: 10.1128/msystems.00387-24

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