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The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

11 Aug 2000

Abstract excerpt

The progressive aggregation and deposition of amyloid beta-protein (Abeta) in brain regions subserving memory and cognition is an early and invariant feature of Alzheimer's disease, the most common cause of cognitive failure in aged humans. Inhibiting Abeta aggregation is therapeutically attractive because this process is believed to be an exclusively pathological event. Whereas many studies have examined the...

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PMID: 10978169
DOI: 10.1021/bi001048s

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