Article
Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo.
European journal of immunology - 1 Jul 2015
Augusto Danillo G, O'Connor Geraldine M, Lobo-Alves Sara C, Bass Sara, Martin Maureen P, Carrington Mary, McVicar Daniel W, Petzl-Erler Maria Luiza
Abstract excerpt
Although HLA-A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any in vivo relevance of this interaction is still missing. To explore the functional importance of KIR3DL2 allelic variation, we analyzed the autoimmune disease pemphigus foliaceus, previously associated (lower risk) with activating KIR genes. KIR3DL2*001 was increased in patients (odds ratio (OR) = 2.04; p = 0.007). The risk was...
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