Article
The activated targets of mTOR signaling pathway are characteristic for PDGFRA mutant and wild-type rather than KIT mutant GISTs.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2011
Sápi Zoltán, Füle Tibor, Hajdu Melinda, Matolcsy András, Moskovszky Linda, Márk Agnes, Sebestyén Anna, Bodoky György
Abstract excerpt
The therapy for gastrointestinal stromal tumors (GISTs) has been revolutionized by tyrosin kinase inhibitors. Clinicopathologic studies have been conducted to assess therapeutical responses in cases with KIT and platelet-derived growth factor receptor α (PDGFRA) gene mutations. Cell culture data suggest that Akt/mammalian target of rapamycin (mTOR) kinase signaling may be important in GIST. The aim of our study...
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