Article
Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence
11 Apr 2015
Abstract excerpt
Understanding of molecular events underlying resistance and relapse in glioblastoma (GBM) is hampered due to lack of accessibility to resistant cells from patients undergone therapy. Therefore, we mimicked clinical scenario in an in vitro cellular model developed from five GBM grade IV primary patient samples and two cell lines. We show that upon exposure to lethal dose of radiation, a subpopulation of GBM cells,...
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