Article
Predicting allele frequencies in DNA pools using high density SNP genotyping data.
Animal genetics - 1 Feb 2011
Peiris B L, Ralph J, Lamont S J, Dekkers J C M
Abstract excerpt
To evaluate the ability to use DNA pools with the Illumina Infinium genotyping platform, two sets of gradient pools were created using two pairs of highly inbred chicken lines. Replicate pools containing 0%, 10%, 20%, 40%, 60%, 80%, 90% and 100% of DNA from line A vs. B or line C vs. D were created, for a total of 28 pools. All pools were genotyped for 12,046 SNPs. Three frequency estimation methods proposed in...
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