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Article

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.

Oncotarget - 8 Sept 2015

Xargay-Torrent Sílvia, López-Guerra Mónica, Rosich Laia, Montraveta Arnau, Roldán Jocabed, Rodríguez Vanina, Villamor Neus, Aymerich Marta, Lagisetti Chandraiah, Webb Thomas R, López-Otín Carlos, Campo Elias, Colomer Dolors

Abstract excerpt

Mutations or deregulated expression of the components of the spliceosome can influence the splicing pattern of several genes and contribute to the development of tumors. In this context, we report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic leukemia (CLL) cells when compared with healthy lymphocytes and tumor cells from other B-lymphoid malignancies, with...

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Source

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Identifiers

PMID: 26068951
DOI: 10.18632/oncotarget.4212
PMCID: PMC4673195

Genes

IBTK
MCL1
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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