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Article

Targeting the 3’ splice site by a decoy oligonucleotide attenuates U2AF1 splicing activity and inhibits leukemia

2026-07-01

Abstract excerpt

Mutations in spliceosomal genes are a hallmark of myeloid malignancies, yet leukemic cells remain dependent on residual splicing activity, exposing a therapeutic vulnerability. Here, we present an RNA decoy strategy that disrupts 3′ splice site recognition by competitively engaging spliceosomal components. We engineered a chemically stabilized RNA decoy that mimics the 3′ splice site (3′SS decoy), sequestering pro...

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Identifiers and source

Literature Corpus work
155af397-69b7-502c-bbac-dee8ae02969a
DOI
10.64898/2026.06.30.735457
Open publication

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Targeting the 3’ splice site by a decoy oligonucleotide attenuates U2AF1 splicing activity and inhibits leukemiaDOI 10.64898/2026.06.30.735457
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