Article
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Molecular neurodegeneration - 23 Nov 2014
Hu Xiaoyan, Li Xiaoling, Zhao Mingrui, Gottesdiener Andrew, Luo Wenjie, Paul Steven
Abstract excerpt
BACKGROUND: The relationship between the pathogenic amyloid β-peptide species Aβ1-42 and tau pathology has been well studied and suggests that Aβ1-42 can accelerate tau pathology in vitro and in vivo. The manners if any in which Aβ1-40 interacts with tau remains poorly understood. In order to answer this question, we used cell-based system, transgenic fly and transgenic mice as models to study the interaction...
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