Article
Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.
Eukaryotic cell - 1 Aug 2012
Fortwendel Jarrod R, Juvvadi Praveen R, Rogg Luise E, Asfaw Yohannes G, Burns Kimberlie A, Randell Scott H, Steinbach William J
Abstract excerpt
Ras is a highly conserved GTPase protein that is essential for proper polarized morphogenesis of filamentous fungi. Localization of Ras proteins to the plasma membrane and endomembranes through posttranslational addition of farnesyl and palmitoyl residues is an important mechanism through which cells provide specificity to Ras signal output. Although the Aspergillus fumigatus RasA protein is known to be a major...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Aspergillus fumigatus
- Cell Membrane
- Fungal Proteins
- Hyphae
- Lipoylation
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Palmitates