Article
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
Nature genetics - 1 Sept 2005
Wang Jianbo, Mark Sharayne, Zhang Xiaohui, Qian Dong, Yoo Seung-Jong, Radde-Gallwitz Kristen, Zhang Yanping, Lin Xi, Collazo Andres, Wynshaw-Boris Anthony, Chen Ping
Abstract excerpt
The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium. It is not certain how this polarity is achieved during differentiation. Here we show that the organ of Corti is formed from a thicker and shorter postmitotic primordium through...
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