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Article

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.

eLife - 10 Apr 2015

Chappell Paul, Meziane El Kahina, Harrison Michael, Magiera Łukasz, Hermann Clemens, Mears Laura, Wrobel Antony G, Durant Charlotte, Nielsen Lise Lotte, Buus Søren, Ternette Nicola, Mwangi William, Butter Colin, Nair Venugopal, Ahyee Trudy, Duggleby Richard, Madrigal Alejandro, Roversi Pietro, Lea Susan M, Kaufman Jim

Abstract excerpt

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship correlates with protective responses against infectious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25860507
DOI: 10.7554/eLife.05345
PMCID: PMC4420994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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