Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.

doi:10.1016/j.it.2018.01.001

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Article

Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.

Trends in immunology - 1 May 2018

Kaufman Jim

Abstract excerpt

In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the chicken MHC is simple and compact with a single dominantly expressed class I molecule that can determine the immune response. In addition to providing useful information for the poultry industry and allowing insights into the evolution of the adaptive immune system, the simplicity of the chicken MHC has allowed the discovery...

Topics

Adaptive Immunity
Alleles
Histocompatibility Antigens Class I
Humans
Major Histocompatibility Complex

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Identifiers

PMID: 29396014
DOI: 10.1016/j.it.2018.01.001
PMCID: PMC5929564

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