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Article

NF‐κB and stat3 transcription factor signatures differentiate HPV ‐positive and HPV ‐negative head and neck squamous cell carcinoma

9 Apr 2015

Abstract excerpt

Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human papillomavirus-related (HPV+) and HPV- HNSCC differed significantly based on the activity levels...

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PMID: 25857630
DOI: 10.1002/ijc.29558

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