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Article

Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma.

Communications biology - 5 Mar 2025

Ren Yanxin, Xiong Wei, Feng Chun, Yu Dan, Wang Xiaoyan, Yang Qing, Yu Siting, Zhang Hongjiang, Huo Bangyun, Jiang Honglu, Li Zuli, Wang Junlin, Su Yu-Xiong, Yang Ping, Liao Yong, Zhong Qi, Wang Junwen

Abstract excerpt

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic studies of 103 Chinese HPSCC patients and observe a higher prevalence and...

Read the complete abstract on PubMed

Topics

Humans
Hypopharyngeal Neoplasms
Male
Female
Prognosis
Squamous Cell Carcinoma of Head and Neck

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proteomics

Middle Aged

Biomarkers, Tumor

Carcinoma, Squamous Cell

Gene Expression Regulation, Neoplastic

Aged

Transcriptome

Mutation

Multiomics

Source

Open in PubMed Open full text

Identifiers

PMID: 40044946
DOI: 10.1038/s42003-025-07700-0
PMCID: PMC11882983

Genes

CCND1
CDKN2A
MUC4
MYC
SOX2

Provenance

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