Article

High Enhancer Activity is an Epigenetic Feature of HPV Negative Atypical Head and Neck Squamous Cell Carcinoma

2021-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with significant morbidity and mortality and frequent recurrence. Pre-NGS efforts to transcriptionally classify HNSCC into groups of varying prognosis have identified four accepted molecular subtypes of disease: Atypical (AT), Basal (BA), Classical (CL), and Mesenchymal (MS). Here, we investigated the active enhancer landsc...

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Literature Corpus work: 268414fc-0c42-53f3-a777-cc53c36a8934
DOI: 10.1101/2021.09.21.461310

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