Article
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.
The Journal of biological chemistry - 22 May 2015
Yuan Fenghua, Dutta Tanmay, Wang Ling, Song Lei, Gu Liya, Qian Liangyue, Benitez Anaid, Ning Shunbin, Malhotra Arun, Deutscher Murray P, Zhang Yanbin
Abstract excerpt
3' repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease. Purified TREX1 displays robust exoribonuclease activity that degrades single-stranded, but not double-stranded, RNA. TREX1-D200N, an Aicardi-Goutieres syndrome disease-causing mutant, is defective in degrading RNA. TREX1 activity is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.