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Genetic Creutzfeldt-Jakob disease-M232R with the cooccurrence of multiple prion strains, M1 + M2C + M2T: Report of an autopsy case.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Jun 2021

Shintaku Masayuki, Nakamura Takeshi, Kaneda Daita, Shinde Akiyo, Kusaka Hirofumi, Takeuchi Atsuko, Kitamoto Tetsuyuki

Abstract excerpt

Genetic Creutzfeldt-Jakob disease (gCJD) with a methionine to arginine substitution at codon 232 of the prion protein gene (gCJD-M232R) is rare and has only been reported in Japan. We report an autopsy case of gCJD-M232R showing alleles of codon 129 that were homozygous for methionine and the presence of multiple strains of the protease-resistant, abnormal isoform of prion protein (PrPSc ), M1 + M2C + M2T. The...

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PMID: 33586250
DOI: 10.1111/neup.12722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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