Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response.

doi:10.1111/gtc.12242

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Article

Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2015

Choi Eun Ju, Yoon Sei Mee, Lee Suman, Lee Jinu

Abstract excerpt

hK2, a member of the kallikrein protease family encoded by KLK2, is expressed exclusively in prostate and is a putative adjunct tumor marker for prostate cancer screening. The T allele of rs198977, a single nucleotide polymorphism in exon 5 of KLK2, codes for W-hK2 and is associated with lower serum hK2 levels and higher risk of prostate cancer than the C allele encoding R-hK2. To elucidate the mechanism that...

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PMID: 25847286
DOI: 10.1111/gtc.12242

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KLK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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