Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An androgen response element mediates LNCaP cell dependent androgen induction of the hK2 gene.

Molecular and cellular endocrinology - 25 Oct 2000

Mitchell S H, Murtha P E, Zhang S, Zhu W, Young C Y

Abstract excerpt

Human glandular kallikrein (hK2) is an androgen regulated protein primarily expressed in the prostate and recently identified as a novel prostate cancer marker. A 5 kb 5' flanking region of the hK2 gene was isolated and sequenced to characterize the regulatory mechanisms for the expression of hK2 in the androgen responsive prostate cell line, LNCaP. Using gene transfer, gel shift, and mutagenesis assays we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgens
Share to Calcitriol
Share to Cell Extracts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholecalciferol

Share to Prostate

Share to Prostate-Specific Antigen

Share to Response Elements

Share to Transfection

Source

Identifiers

PMID: 11064155
DOI: 10.1016/s0303-7207(00)00319-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An androgen response element mediates LNCaP cell dependent androgen induction of the hK2 gene.PMID 11064155Read ↗

Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element.Semantic proximity Read ↗

Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein LocusSemantic proximity Read ↗

Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.Semantic proximity Read ↗

Cooperative Assembly of Androgen Receptor into a Nucleoprotein Complex That Regulates the Prostate-specific Antigen EnhancerSemantic proximity Read ↗

An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter.Semantic proximity Read ↗

Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response.Semantic proximity Read ↗

Locus-Wide Chromatin Remodeling and Enhanced Androgen Receptor-Mediated Transcription in Recurrent Prostate Tumor CellsSemantic proximity Read ↗

Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate CancerSemantic proximity Read ↗

Human Kallikrein 2 (hK2) and Prostate-Specific Antigen (PSA): Two Closely Related, but Distinct, Kallikreins in the ProstateSemantic proximity Read ↗

Kallikrein 4 Is a Proliferative Factor that Is Overexpressed in Prostate CancerSemantic proximity Read ↗

Relative concentrations of hK2/PSA mRNA in benign and malignant prostatic tissueSemantic proximity Read ↗

Identification of Androgen Response Elements in the Insulin-Like Growth Factor I Upstream PromoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.