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Article

Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate Cancer

1 Apr 2004

Abstract excerpt

Kallikreins (KLKs) are highly conserved serine proteases that play key roles in a variety of physiological and pathological processes. KLKs are secreted proteins that have extracellular substrates and function. For example, prostate-specific antigen (or KLK3) is a secreted protein that is widely used as a diagnostic marker for prostate cancer. KLK4 is a recently identified member of the kallikrein family that is...

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PMID: 15059887
DOI: 10.1158/0008-5472.can-03-2025

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Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate CancerPMID 15059887Read ↗

Kallikrein 4 Is a Proliferative Factor that Is Overexpressed in Prostate CancerSemantic proximity Read ↗

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Identification and Characterization of KLK-L4, a New Kallikrein-like Gene That Appears to be Down-regulated in Breast Cancer TissuesSemantic proximity Read ↗

Unusual Alternative Splicing within the Human Kallikrein Genes KLK2 and KLK3 Gives Rise to Novel Prostate-specific ProteinsSemantic proximity Read ↗

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Genetic association of the KLK4 locus with risk of prostate cancer.Semantic proximity Read ↗

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease*Semantic proximity Read ↗

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Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevanceSemantic proximity Read ↗

Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?Semantic proximity Read ↗

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