Article
Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2006
Nam Robert K, Zhang William W, Klotz Laurence H, Trachtenberg John, Jewett Michael A S, Sweet Joan, Toi Ants, Teahan Seamus, Venkateswaran Vasundara, Sugar Linda, Loblaw Andrew, Siminovitch Kathy, Narod Steven A
Abstract excerpt
PURPOSE: Increased levels of serum human kallikrein-2 (hK2) and an hK2 gene (KLK2) variant are positively associated for prostate cancer, but the relationships between them remain unclear. We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels. EXPERIMENTAL DESIGN: We genotyped 645 men with biopsy-proven prostate cancer (cases) and 606 males...
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