Article
Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.
AIDS research and human retroviruses - 1 Jun 2015
Saravanan Shanmugam, Gomathi Selvamurthi, Kausalya Bagavathi, Boobalan Jayaseelan, Murugavel Kailapuri G, Balakrishnan Pachamuthu, Mothi Sarvode N, Solomon Sunil S, Kumarasamy Nagalingeswaran, Selvamuthu Poongulali, Solomon Suniti, Smith Davey M
Abstract excerpt
In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.