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Article

Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children.

PLoS pathogens - 1 Dec 2012

Sturdevant Christa Buckheit, Dow Anna, Jabara Cassandra B, Joseph Sarah B, Schnell Gretja, Takamune Nobutoki, Mallewa Macpherson, Heyderman Robert S, Van Rie Annelies, Swanstrom Ronald

Abstract excerpt

HIV-1 subtype B replication in the CNS can occur in CD4+ T cells or macrophages/microglia in adults. However, little is known about CNS infection in children or the ability of subtype C HIV-1 to evolve macrophage-tropic variants. In this study, we examined HIV-1 variants in ART-naïve children aged three years or younger to determine viral genotypes and phenotypes associated with HIV-1 subtype C pediatric CNS...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

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Share to Receptors, CCR5

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Source

Open in PubMed Open full text

Identifiers

PMID: 23300446
DOI: 10.1371/journal.ppat.1003094
PMCID: PMC3531524

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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