Article
Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population.
Human immunology - 1 Sept 2008
Zervou Maria I, Sidiropoulos Prodromos, Petraki Eleni, Vazgiourakis Vassilios, Krasoudaki Eleni, Raptopoulou Amalia, Kritikos Herakles, Choustoulaki Eva, Boumpas Dimitrios T, Goulielmos George N
Abstract excerpt
Rheumatoid arthritis (RA) is a multifactorial disease that is increasing in incidence worldwide. It is associated with a complex mode of inheritance, with many genes being involved in the development and progression of the disease. Genome-wide association studies in different populations have recently revealed a significant association between a TRAF1/C5 and a STAT4 polymorphism and the development of RA. In the...
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