Article
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
The New England journal of medicine - 20 Sept 2007
Plenge Robert M, Seielstad Mark, Padyukov Leonid, Lee Annette T, Remmers Elaine F, Ding Bo, Liew Anthony, Khalili Houman, Chandrasekaran Alamelu, Davies Leela R L, Li Wentian, Tan Adrian K S, Bonnard Carine, Ong Rick T H, Thalamuthu Anbupalam, Pettersson Sven, Liu Chunyu, Tian Chao, Chen Wei V, Carulli John P, Beckman Evan M, Altshuler David, Alfredsson Lars, Criswell Lindsey A, Amos Christopher I, Seldin Michael F, Kastner Daniel L, Klareskog Lars, Gregersen Peter K
Abstract excerpt
BACKGROUND: Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis. METHODS: We genotyped 317,503 single-nucleotide...
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