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Article

Membrane anchor of cytochrome P450 reductase suppresses the uncoupling of cytochrome P450.

Chemical & pharmaceutical bulletin - 1 Jan 2015

Miyamoto Masayoshi, Yamashita Taku, Yasuhara Yuki, Hayasaki Akinori, Hosokawa Yukari, Tsujino Hirofumi, Uno Tadayuki

Abstract excerpt

Cytochrome P450 reductase (CPR) is an important redox partner of microsomal CYPs. CPR is composed of a membrane anchor and a catalytic domain that contains FAD and flavin mononucleotide (FMN) as redox centers and mediates electron transfer to CYP. Although the CPR membrane anchor is believed to be requisite for interaction with CYP, its physiological role is still controversial. To clarify the role of the anchor,...

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PMID: 25832023
DOI: 10.1248/cpb.c15-00034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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