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Article

Restoration of mutant cytochrome P450 reductase activity by external flavin.

Molecular and cellular endocrinology - 10 Jun 2010

Nicolo Catherine, Flück Christa E, Mullis Primus E, Pandey Amit V

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) supplies electrons from NADPH to steroid and drug metabolizing reactions catalyzed by the cytochrome P450s located in endoplasmic reticulum. Mutations in human POR cause a wide spectrum of disease ranging from disordered steroidogenesis to sexual differentiation. Previously we and others have shown that POR mutations can lead to reduced activities of steroidogenic P450s...

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Source

Identifiers

PMID: 20188793
DOI: 10.1016/j.mce.2010.02.024

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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