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B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

Kidney international - 1 Sept 2015

Shiu Kin Y, McLaughlin Laura, Rebollo-Mesa Irene, Zhao Jingyue, Semik Vikki, Cook H Terence, Roufosse Candice, Brookes Paul, Bowers Robert W, Galliford Jack, Taube David, Lechler Robert I, Hernandez-Fuentes Maria P, Dorling Anthony

Abstract excerpt

We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14 patients with AMR and 5 with no pathology on protocol; 38 with AMR and 8 with nonimmunologic damage on 'for cause'. Using...

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PMID: 25830760
DOI: 10.1038/ki.2015.100

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