Article
Transitional B lymphocytes are associated with protection from kidney allograft rejection: a prospective study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 May 2015
Shabir S, Girdlestone J, Briggs D, Kaul B, Smith H, Daga S, Chand S, Jham S, Navarrete C, Harper L, Ball S, Borrows R
Abstract excerpt
Recent cross-sectional studies suggest an important role for transitional B lymphocytes (CD19 + CD24hiCD38hi) in promoting transplant tolerance, and protecting from late antibody-mediated rejection (ABMR). However, prospective studies are lacking. This study enrolled 73 de novo transplant recipients, and collected serial clinical, immunological and biochemical information over 48 ± 6 months. Cell phenotyping was...
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