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Article

Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.

Journal of molecular biology - 12 Jul 2002

Dimasi Nazzareno, Sawicki Mark W, Reineck Lora A, Li Yili, Natarajan Kannan, Margulies David H, Mariuzza Roy A

Abstract excerpt

Natural killer (NK) cells play a crucial role in the detection and destruction of virally infected and tumor cells during innate immune responses. The cytolytic activity of NK cells is regulated through a balance of inhibitory and stimulatory signals delivered by NK receptors that recognize classical major histocompatabilty complex class I (MHC-I) molecules, or MHC-I homologs such as MICA, on target cells. The...

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Share to Antigens, Ly
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lectins, C-Type

Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Protein Structure, Quaternary

Share to Receptors, Immunologic

Share to Receptors, Natural Killer Cell

Source

Identifiers

PMID: 12096910
DOI: 10.1016/s0022-2836(02)00498-9

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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