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Article

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.

Nature immunology - 1 Aug 2005

Zajonc Dirk M, Cantu Carlos, Mattner Jochen, Zhou Dapeng, Savage Paul B, Bendelac Albert, Wilson Ian A, Teyton Luc

Abstract excerpt

Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the...

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Source

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Identifiers

PMID: 16007091
DOI: 10.1038/ni1224
PMCID: PMC2045075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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