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Article

Cytotoxic and apoptotic effects of recombinant subtilase cytotoxin variants of shiga toxin-producing Escherichia coli.

Infection and immunity - 1 Jun 2015

Funk J, Biber N, Schneider M, Hauser E, Enzenmüller S, Förtsch C, Barth H, Schmidt H

Abstract excerpt

In this study, the cytotoxicity of the recently described subtilase variant SubAB2-2 of Shiga toxin-producing Escherichia coli was determined and compared to the plasmid-encoded SubAB1 and the chromosome-encoded SubAB2-1 variant. The genes for the respective enzymatic active (A) subunits and binding (B) subunits of the subtilase toxins were amplified and cloned. The recombinant toxin subunits were expressed and...

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Identifiers

PMID: 25824835
DOI: 10.1128/IAI.00231-15
PMCID: PMC4432763

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