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Article

Pharmacogenomics of platinum-based chemotherapy in NSCLC

15 May 2009

Abstract excerpt

NSCLC is the leading cause of cancer-related death in the US. Patients with NSCLC are mostly treated with platinum-based chemotherapy, often in combination with radiation therapy. However, the development of chemo-resistance is a major hurdle limiting treatment success. In this review, we summarize the current understanding of the genetic factors modulating chemoresistance to platinum chemotherapeutics and their...

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PMID: 19442035
DOI: 10.1517/17425250902973711

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